pentobarbital will reduce the extent or effect of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will lower the level or result of finasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
Watch Closely (2)pentobarbital will lessen the extent or impact of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. If coadministration by using a CYP3A4 inducer is essential, contemplate raising oliceridine dose till steady drug outcomes are obtained; monitor for signs of opioid withdrawal.
pentobarbital will lower the level or result of buprenorphine subdermal implant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Observe patients currently on buprenorphine subdermal implant who demand recently-initiated treatment method with CYP3A4 inducer for symptoms and signs and symptoms of withdrawal.
pentobarbital will decrease the extent or result of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Sturdy or reasonable CYP3A4 inducers may perhaps increase rate of diazepam elimination; hence, efficacy of diazepam might be lessened.
pentobarbital will reduce the extent or result of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
CYP3A4 inducers may perhaps boost the development from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Carefully monitor sufferers having ifosfamide with CYP3A4 inducers for toxicities and look at dose adjustment.
Comment: Barbiturates may perhaps enhance adverse effects, which include respiratory depression, produced by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
pentobarbital will lower the level or impact of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
pentobarbital will decrease the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. The efficacy of hormonal contraceptives might be reduced.
With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
pentobarbital will minimize the level or result of elagolix by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Right after stopping a CYP3A4 inducer, as the results of your inducer decline, the fentanyl plasma concentration will enhance which could raise or lengthen each the therapeutic and adverse results.
Remark: Barbiturates may perhaps maximize adverse consequences, including respiratory depression, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood check here concentrations of TCAs.